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AMPK has also been shown to promote biogenesis through the regulation of PGC-1α (Palikaras et al., 2015), while mitophagy is upregulated by the enhancement of mitochondrial fission and TBK1-activated autophagosome engulfment in a PINK1-Parkin-independent pathway (Seabright et al., 2020)

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Access the full publication through NEJM.org for detailed methodology, adverse event data, and subgroup analyses